Indications:

Treatment of chronic hepatitis C virus (HCV) infection in adults and children (≥6 years or weighing ≥17 kg).

Dosage & Administration:

• Standard dose: One tablet (400mg/100mg) once daily, taken orally with or without food.

• Swallow whole—do not crush, split, or chew the film-coated tablet.

• Missed dose: Take as soon as remembered if ≤18 hours late; otherwise, skip and resume the next day. Do not double dose.

Treatment Duration:

• Genotypes 1–6 without cirrhosis or with compensated cirrhosis: 12 weeks.

• Genotype 3 with cirrhosis (in some cases): May require ribavirin (as prescribed).

Precautions:

1. Drug Interactions (consult doctor before taking with):

• Strong CYP inducers (e.g., rifampin, carbamazepine, St. John’s wort)—may reduce efficacy.

• Acid-reducing agents (PPIs, H2 blockers): Take 4 hours before omeprazole or famotidine.

• Amiodarone: Contraindicated (risk of severe bradycardia).

2. Liver & Kidney Function:

• Safe in mild to moderate liver/kidney impairment; monitor if severe.

• Not recommended in severe decompensated cirrhosis (use alternative regimens).

3. Pregnancy/Breastfeeding:

• No safety data—use only if clearly needed.

• Velpatasvir may pass into breast milk (consult doctor).

Common Side Effects:

• Fatigue, headache

• Nausea, diarrhea

• Mild rash

Storage:

Keep at room temperature (below 30°C), in original packaging.

Note: Confirm HCV genotype and liver status before treatment.