Indication:

Treatment of thrombocytopenia (low platelet counts) in:

            ●    Chronic immune thrombocytopenia (ITP) (adults & children ≥1 year).

            ●    Chronic hepatitis C-associated thrombocytopenia (with antiviral therapy).

            ●    Severe aplastic anemia (in combination with immunosuppressants).

Dosage & Administration:

            ●    Standard dose: 50mg once daily (dose may vary; follow doctor’s instructions).

            ●    Take on an empty stomach: At least 1 hour before or 2 hours after meals.

            ●    Avoid calcium-rich foods/dairy, antacids, or supplements within 4 hours of dosing (they reduce absorption).

            ●    Swallow whole—do not crush, split, or chew the film-coated tablet.

            ●    Missed dose: Skip if forgotten; do not double the next dose.

Important Precautions:

    1. Liver Monitoring:

            ●    Requires regular liver function tests (LFTs) (risk of hepatotoxicity).

            ●    Dose adjustments needed for hepatic impairment.

    2. Bone Marrow Fibrosis:

            ●    May increase risk with long-term use; monitor blood counts.

    3. Thrombosis Risk:

            ●    High platelet counts can raise clotting risk; report unusual swelling/pain.

    4. Drug Interactions:

            ●    Avoid with antacids, iron/zinc supplements, or CYP3A4 inducers/inhibitors (e.g., rifampin, ketoconazole).

Common Side Effects:

            ●    Headache, nausea, diarrhea

            ●    Fatigue, abnormal liver tests

            ●    Rash, increased risk of infections

Storage:

Keep at room temperature (15–30°C), in original packaging to protect from moisture.

Note: Dosing for ITP and hepatitis C differs; always follow your prescriber’s instructions.